Job Summary
We are seeking a graduate student for a research internship at Iambic Therapeutics to contribute to the development of NeuralPLexer, our protein structure prediction platform. This internship offers an exciting opportunity to work on cutting-edge machine learning approaches for structural biology, with a focus on understanding protein conformational dynamics and affinity. You will join a collaborative team developing next-generation methods that combine deep learning with physics-based approaches.
Key Responsibilities
- Help develop and train deep learning models for protein structure prediction
- Work with molecular dynamics simulations and enhanced sampling techniques to validate and improve model predictions
- Analyze large-scale protein structural data to identify patterns in conformational changes
- Assist in implementing new model architectures and training strategies
- Contribute to our model evaluation framework, particularly for conformational accuracy
- Participate in team meetings and present findings to the computational group
PREFERRED QUALIFICATIONS:
- Currently enrolled in a PhD program in Computational Chemistry, Computational Biophysics, Computer Science, Computational Biology, or related field
- Experience with Python
- Experience with enhanced sampling and classical molecular dynamics simulations
- Experience with deep learning frameworks (PyTorch preferred)
- Understanding of protein structure and protein dynamics
- Interest in scientific machine learning applications
LEARNING OPPORTUNITIES
- Work with state-of-the-art protein structure prediction models
- Learn to integrate physical principles into machine learning approaches
- Gain experience with enhanced sampling methods
- Understand real-world applications in drug discovery
- Collaborate with experts in both ML and computational chemistry
Duration: 3-9 months (flexible based on academic schedule)
Location: San Diego
This is a paid internship.
About Iambic Therapeutics
Founded in 2019 and headquartered in San Diego, California, Iambic Therapeutics is disrupting the therapeutics landscape with its unique AI-driven drug-discovery platform. Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters with strong track records of success in delivering clinically validated therapeutics. The Iambic platform has been demonstrated to deliver high-quality, differentiated therapeutics to clinical stage with unprecedented speed and across multiple target classes and mechanisms of action. The Iambic team is advancing an internal pipeline of clinical assets to address urgent unmet patient needs. Learn more about the Iambic team, platform, and pipeline at iambic.ai.
MISSION & CORE VALUES
The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
ALSO
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
